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目的探讨非免疫性胎儿水肿(NIHF)与人微小病毒(HPV-B19)感染的关系,以及HPV-B19病毒感染的发病机制、病理特点和检测方法等。方法回顾性分析13例非免疫性胎儿水肿的尸检资料及临床资料,复习相关的文献,对13例尸检病例的胎盘组织应用实时荧光定量聚合酶链反应方法进行HPV-B19病毒等5项微生物检测,分析HPV-B19病毒在非免疫性胎儿水肿中感染的情况。结果 13例中2例伴有胎儿颈部淋巴管水囊瘤,6例同时合并其他脏器畸形,1例染色体检查为21-三体。13例中2例HPV-B19病毒(+)。结论 HPV-B19病毒感染是引起非免疫性胎儿水肿的重要病因之一。实时荧光定量PCR技术可以是确定HPV-B19病毒感染较好的检测方法。
Objective To investigate the relationship between non-immune fetal edema (NIHF) and human parvovirus (HPV-B19) infection and the pathogenesis, pathological features and detection of HPV-B19 infection. Methods The autopsy data and clinical data of 13 cases of non-immune fetal edema were retrospectively reviewed. The related literatures were reviewed. The placental tissues of 13 cases of autopsy were detected by real-time fluorescence quantitative polymerase chain reaction (PCR-RFLP) , Analysis of HPV-B19 virus infection in non-immune fetal edema situation. Results Of the 13 cases, 2 cases were accompanied with lymphatic tumor of the neck of the fetus, 6 cases were complicated with other organ deformities, and 1 case had chromosome 21-trisomy. Two of the 13 cases were HPV-B19 (+). Conclusion HPV-B19 virus infection is one of the important causes of non-immune fetal edema. Real-time fluorescence quantitative PCR technology can be a better detection method to determine HPV-B19 virus infection.