目的比较两种根管封闭剂在根管充填后的临床疗效。方法选取临床需要根管治疗的患牙120颗,随机分为2组,分别采用Cortisomol糊剂和氧化锌丁香油糊剂进行冷侧方加压法根充,并对2组术后临床疗效进行比较分析。结果根充后两组疼痛发生率有统计学差异。结论 Cortisomol封闭剂可以有效减少根充术后反应,为临床使用根管封闭剂提供依据。 Objective To compare the clinical effects of two kinds of root canal sealant after root canal filling. Methods 120 teeth with clinical need of root canal treatment were randomly divided into 2 groups. Cortisomol paste and zinc oxide clove oil paste were respectively used for cold lateral compression. The clinical curative effect of 2 groups comparative analysis. Results The incidence of pain in the two groups after root filling was statistically different. Conclusion Cortisomol blocking agent can effectively reduce the response after root canal filling and provide the basis for the clinical use of root canal sealant.