论文部分内容阅读
目的 探讨血管内皮生长因子 (VEGF)和微血管生成与肾癌发展的关系。 方法 应用免疫组化技术检测 46例肿瘤组织中的VEGF。 结果 46例肿瘤组织中VEGF阳性表达 2 8例(6 0 8% )、微血管密度 (MVD)为 6 3 6 4± 33 2 0 ,均显著高于正常组织。VEGF、MVD与肿瘤的组织类型无关 (P >0 0 5 ) ,与肿瘤的组织学分级有关 (P <0 0 5 ) ;VEGF阳性组MVD明显高于阴性组 (P <0 0 5 ) ;有淋巴结转移组VEGF、MVD均高于无淋巴结转移组 (P <0 0 5 ) ;VEGF阳性组术后 5年复发转移率明显高于阴性组 (P <0 0 1)。 结论 VEGF与肾癌的血管生成有关 ,VEGF和MVD可作为反映肾细胞癌生物学行为的指标之一
Objective To investigate the relationship between vascular endothelial growth factor (VEGF) and angiogenesis and the development of renal cell carcinoma. Methods Immunohistochemical technique was used to detect VEGF in 46 cases. Results The positive expression of VEGF in 28 cases (60.8%) and microvessel density (MVD) in 46 cases of tumor tissues were 6 364 ± 33 2 0, which were significantly higher than those in normal tissues. VEGF and MVD were not related to tumor type (P> 0.05), but correlated with histological grade of tumor (P <0.05); MVD in VEGF positive group was significantly higher than that in negative group (P <0 05) The VEGF and MVD in lymph node metastasis group were significantly higher than those in non-lymph node metastasis group (P <0.05). The recurrence and metastasis rate in 5-year group was significantly higher than that in negative group (P <0.01). Conclusions VEGF is associated with angiogenesis of renal cell carcinoma, and VEGF and MVD may be one of the indicators reflecting the biological behavior of renal cell carcinoma