各种肾脏疾病的晚期,除原来致病因素可继续造成肾损害外,其他因素如高蛋白饮食、高钠饮食以及持续的高血压等均可增加残存肾单位的负担,使肾单位血流量增加,肾小球入球小动脉扩张,滤出液增多,从而加速毛细血管及系膜的硬化以致病情恶化,当残存的肾单位减少到不能维持正常肾排泄功能时就出现 In addition to the original pathogenic factors can continue to cause kidney damage, other factors such as high-protein diet, high sodium diet and persistent high blood pressure can increase the burden of residual nephrons, so that nephron blood flow increased , Glomerular access arterioles dilated, increased filtrate, thus accelerating the hardening of the capillaries and mesangial resulting in deterioration, when the remaining nephron reduced to not maintain normal renal excretion function appeared