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目的探讨人体呼出气中总挥发性有机物(volatile organic conmpounds,VOCs)的浓度水平是否与疾病之间存在关联,进而指导疾病早期诊断。方法选取武警某三甲医院收治的100例呼吸系统疾病患者为观察对象,分为4组:肺癌组(n=15)、肺炎组(n=55)、肺纤维化组(n=15)、慢性阻塞性肺疾病(chronic obstructive pulmonary diseases,COPD)组(n=15);同时选取我院81例健康医护人员作为对照组。用光离子化探测器(photoionization detector,PID)测定所有对象呼出气中总VOCs浓度(标记为Pvoc)。结果与健康对照组相比,肺癌组(Z=-2.523,P=0.012)、肺炎组(Z=-4.281,P<0.001)、肺纤维化组(Z=-3.204,P=0.001)及COPD组(Z=-2.644,P=0.008)Pvoc测定结果均明显降低,差异均有统计学意义。而肺癌组、肺炎组、肺纤维化组与COPD组之间Pvoc两两比较,差异均无统计学意义。结论用PID测定人体呼出气总VOCs浓度无助于对肺癌、肺炎、肺纤维化、COPD患者的诊断。
Objective To explore whether there is a relationship between the concentration of volatile organic compounds (VOCs) in human exhaled breath and the disease, so as to guide the early diagnosis of the disease. Methods A total of 100 cases of respiratory diseases were selected from a top three military hospital of Armed Police Forces and divided into 4 groups: lung cancer group (n = 15), pneumonia group (n = 55), pulmonary fibrosis group (n = 15) Chronic obstructive pulmonary diseases (COPD) group (n = 15); at the same time we selected 81 cases of health care workers in our hospital as a control group. The total VOCs concentration (marked as Pvoc) in the exhaled breath of all subjects was determined using a photoionization detector (PID). Results Compared with healthy controls, the lung cancer group (Z = -2.523, P = 0.012), pneumonia group (Z = -4.281, P <0.001), pulmonary fibrosis group (Z = -3.204, P = 0.001) Group (Z = -2.644, P = 0.008) Pvoc test results were significantly lower, the differences were statistically significant. There was no significant difference in Pvoc between lung cancer group, pneumonia group, pulmonary fibrosis group and COPD group. Conclusion The determination of the total VOCs concentration of exhaled breath in a human body by PID is not helpful for the diagnosis of lung cancer, pneumonia, pulmonary fibrosis and COPD.