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目的探讨卡前列素氨丁三醇用于产后出血的疗效及对纤维蛋白原与D-二聚体的影响。方法以2013年6月至2017年3月广州市白云区中医院收治的50例产后出血患者为研究对象,以电脑随机方式,将本研究中纳入的对象随机分为研究组与常规组,各25例。常规组产后予以缩宫素治疗,研究组产后应用卡前列素氨丁三醇治疗,对两组患者临床治疗效果进行统计分析,并比较其治疗前后纤维蛋白原、D-二聚体水平、产后出血量以及恶露持续时间、宫缩时间、子宫底下降速度。结果研究组临床治疗总有效率为96.0%,常规组临床治疗总有效率为80.0%,组间疗效比较,研究组高于常规组,差异有统计学意义(P<0.05);治疗后,两组纤维蛋白原、D-二聚体水平较治疗前均有所降低,但研究组低于常规组,组间比较差异有统计学意义(P<0.05);术后2 h出血量、24 h出血量比较,研究组低于常规组,差异均统计学意义(均P<0.05);与常规组比较,研究组子宫底下降速度更快、恶露持续时间更短,宫缩时间更长,差异均统计学意义(均P<0.05)。结论针对产后出血患者应用卡前列素氨丁三醇治疗,效果显著,不仅有利于减低患者术后出血量,而且还能够帮助患者缓解高凝血状态,优势突出。
Objective To investigate the effect of carboprost trometamol on postpartum hemorrhage and its effect on fibrinogen and D-dimer. Methods Fifty patients with postpartum hemorrhage treated in Guangzhou Baiyun District Chinese Medicine Hospital from June 2013 to March 2017 were randomly divided into study group and conventional group randomly 25 cases. The conventional group was treated with oxytocin after giving birth. The study group was treated with carboprost with trometamol postpartum, and the clinical effects of the two groups were statistically analyzed. The levels of fibrinogen and D-dimer before and after treatment were compared, and the postpartum Bleeding volume and duration of lochia, contractions time, the rate of decline at the end of the uterus. Results The total effective rate of clinical treatment was 96.0% in study group and 80.0% in conventional group. The curative effect was better in study group than in conventional group (P <0.05). After treatment, Group fibrinogen, D-dimer levels were lower than before treatment, but the study group was lower than the conventional group, the difference was statistically significant (P <0.05); 2 h postoperative bleeding, 24 h Bleeding volume, the study group was lower than the conventional group, the difference was statistically significant (all P <0.05); compared with the conventional group, the study group, the declining rate of the uterus at the bottom faster, shorter duration of lochia, contractions longer, the difference All were statistically significant (all P <0.05). Conclusion The application of carboprost trometamol in patients with postpartum hemorrhage has significant effect, which is not only helpful to reduce postoperative blood loss, but also can help patients to relieve hypercoagulable state with prominent advantages.