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AIM To reveal the inhibitory effects ofCurcuma aromatica oil(CAO)on cellproliferation of hepatoma in mice.METHODS Two tumor inhibitory experimentsof CAO on hepatoma in mice were conducted.The inhibitory effects of CAO on proliferation ofhepatoma in mice were evaluated by DNA imagecytometry and immunohistochemical staining ofproliferating cell nuclear antigen(PCNA).RESULTS The tumor inhibitory rates of CAOwere 52% and 51% in two experiments,respectively.Compared with those of the saline-treated control groups,both differences werestatistically significant(P<0.01).In the groupof mice treated with CAO,the cellular nuclearDNA OD value(249±70),areas(623 μm~2±228 μm~2)and DNA(2.38±0.67)index of hepaticcarcinomas were significantly lower than thoseof the control group(430±160,1073 μm~2±101 μm~2 and 4.48±0.71).CAO also couldincrease diploidy cell rates(29.00%±9.34% vs2.97%±5.69%,P<0.01)and decreasepentaploidy cell exceeding rate(30.04%±15.10% vs 70.89%±14.94%,P<0.01).In thegroup of mice treated with CAO,the labelingindexes of proliferating cell nuclear antigen (PCNA-LI)were 30%±4%,which weresignificantly lower than 40%±6% of the controlgroup(P<0.01).CONCLUSION The inhibition of CAO on thegrowth of hepatoma in mice might be associatedwith its depression on cellular proliferativeactivity.
AIM To reveal the inhibitory effects ofCurcuma aromatica oil(CAO) on cellproliferation of hepatoma in mice.METHODS Two tumor inhibitory experimentsof CAO on hepatoma in mice was conducted.The inhibitory effects of CAO on proliferation ofhepatoma in mice were evaluated by DNA imagecytometry and immunohistochemical staining Ofproliferating cell nuclear antigen(PCNA).RESULTS The tumor inhibitory rates of CAOwere 52% and 51% in two experiments,respectively.Compared with those of the saline-treated control groups,both differences were statistically significant(P<0.01).In the groupof Mice treated with CAO, the cellular nuclear DNA OD value (249±70), areas (623 μm~2±228 μm~2), and DNA (2.38±0.67) index of hepatic carcinomas were significantly lower than those of the control group (430±160). , 1073 μm~2±101 μm~2 and 4.48±0.71).CAO also could increase the diploidy cell rates (29.00%±9.34% vs2.97%±5.69%, P<0.01) and decreasepentaploidy cell exceeding rate (30.04%±15.10 % vs 70.89%±14.94%, P<0.01). In thegroup Of mice treated with CAO, the labeling indexes of proliferating cell nuclear antigen (PCNA-LI)were 30%±4%,which were significantly higher than 40%±6% of the controlgroup (P<0.01).CONCLUSION The inhibition of CAO on the growth Of hepatoma in mice might be associatedwith its depression on cellular proliferativeactivity.