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恶性肿瘤的免疫学治疗研究转移性黑瘤的常规治疗,包括手术、化疗与放疗,新的治疗趋势是开展被动或主动免疫学处理。恶性黑瘤采用免疫学治疗有特殊意义,因为这种肿瘤有相当的致免疫性,表达出独具的细胞膜蛋白和脂质抗原。主动特异性免疫治疗的临床观察,发现用瘤苗和BCG共同接种,可使浸润的Ⅰ期、和转移的Ⅱ期黑瘤患者的生存期延长。其它的研究表明Ⅱ期病人经用一种病毒肿瘤溶解物免疫后,产生了特异性抗体,和单用BCG病人组相比。其生存期有所延长。被动性免疫治疗包括采用LAK细胞或TIL细胞与白细胞介素一2(IL-
Immunological treatment of malignant tumors Conventional studies of metastatic melanoma, including surgery, chemotherapy, and radiation therapy, have a new trend toward passive or active immunological treatments. The use of immunological therapy for malignant melanoma is of special significance because the tumor is quite immunogenic and expresses unique cell membrane proteins and lipid antigens. Clinical observation of active specific immunotherapy found that co-inoculation with tumor vaccines and BCG can prolong the survival of patients with invasive stage I and metastatic stage II melanoma. Other studies have shown that stage II patients were immunized with a viral tumor lysate and produced specific antibodies compared to the BCG alone group. Its survival has been extended. Passive immunotherapy includes the use of LAK cells or TIL cells and IL-2 (IL-