莱姆病是一种由婢传播的感染性疾病，１９７５年首先在美国发现，８０年代国内陆续有人报道。本病是一种可累及多个系统的疾病。以发作性头痛为主要表现者尚未见报道。本文报道两例以发作性头痛为主要表现的莱姆病，对其临床特征进行了描述，并对其治疗进行了讨论。作者指出，及时明确诊断对于莱姆病头痛的治疗十分重要。 Lyme disease is a contagious disease transmitted by gall bladder. It was first discovered in the United States in 1975 and gradually reported in China in the 1980s. The disease is a disease that can affect multiple systems. As the main manifestation of episodic headaches have not been reported. This article reports two cases of Lyme disease with episodic headache as the main manifestation of its clinical features were described, and its treatment were discussed. The authors point out that timely and definitive diagnosis of the treatment of Lyme disease headache is very important.