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在用ＤＮＡ指纹为建立葡萄胎动物模型选择动物的过程中，发现“三种”不同来源的ＢＡＬＢ／Ｃ小鼠（分别称为Ｂ、Ｂ１和Ｂ２，Ｂ为保种培养的无污染ＢＡＬＢ／Ｃ）的ＤＮＡ指纹出现了明显差别。与标准的保种品系Ｂ相比，Ｂ１和Ｂ２在１２ｋｂ各缺失了一条ＤＮＡ片段，Ｂ１还缺失了６６ｋｂ的片段，而在６ｋｂ处Ｂ１和Ｂ２都增加了一条ＤＮＡ片段。根据Ｊｅｆｒｅｙｓ的统计，每个小卫星ＤＮＡ位点发生ＤＮＡ指纹可观测性突变的概率为１０－３，而本文结果为５个片段发生变化，如视为突变，其概率为（１０－３）５，即１０－１５，可能性近乎０，所以，可以完全排除这些带纹的差异是由突变造成的，而将这样的差异确定为遗传污染更有道理，而且是亲缘关系较近的品系间的污染。
In the selection of animals by DNA fingerprinting for the establishment of a hydatidiform animal model, “three” BALB / c mice of different origin (B, B1 and B2, respectively, identified as non-contaminating BALB / C ) DNA fingerprints appeared a significant difference. Compared with the standard maintainer line B, B1 and B2 each lacked a DNA fragment at 12kb, while B1 also lost a 66kb fragment, whereas a DNA fragment was added at both B1 and B2 at 6kb. According to Jefreys’s statistics, the probability of DNA fingerprinting mutations in each mini-satellite DNA site is 10-3, whereas in this paper, there are 5 fragments that have a mutation probability of (10-3) 5 , That is, 10-15, the probability is almost 0, so we can completely exclude these differences are caused by mutations in the strip, and to make such a difference identified as genetic pollution more reasonable, and is between close relatives of the line Pollution.