用循环伏安法、示差脉冲伏安法和紫外光谱法研究了抗癌药物6-巯基嘌呤与DNA的相互作用。在pH 5.6的乙酸缓冲溶液中,两者以静电形式结合形成1:1的缔合物,其缔合物为非电活性化合物,结合常数是5.17×10~6。同时对DNA与6-MP电极过程机理进行了研究,并求得了电极过程动力学参数。 Cyclic voltammetry, differential pulse voltammetry and UV spectroscopy were used to study the interaction of the anti-cancer drug 6-mercaptopurine with DNA. In pH 5.6 acetic acid buffer solution, the two are electrostatically bound to form a 1: 1 association, the association of non-electroactive compounds, the binding constant is 5.17 × 10 ~ 6. At the same time, the mechanism of DNA and 6-MP electrode process was studied, and the electrode kinetic parameters were obtained.