糖尿病肾脏疾病(diabetic kidney disease,DKD)是糖尿病(diabetes mellitus,DM)最常见并发症,是引起终末期肾脏疾病(end stage renal disease,ESRD)的主要原因之一。足细胞是位于肾小球基底膜(glomerular basement membrane,GBM)外侧的高度分化的细胞,有高度的结构和功能特异性,在维持肾小球滤过屏障的结构和功能上起着重要的作用。近年来研究发现足细胞损伤在DKD的发病机制中起着关键性作用。足细胞损伤机制的研究是肾脏疾病领域的研究热点,但其损伤机制仍未完全阐明。本文就DKD足细胞损伤机制研究进展作一综述。 Diabetic kidney disease (diabetic kidney disease, DKD) is one of the most common complications of diabetes mellitus (DM), which is one of the main causes of end stage renal disease (ESRD). Podocytes, which are highly differentiated cells located outside the glomerular basement membrane (GBM), are highly structural and functional specific and play an important role in maintaining the structure and function of the glomerular filtration barrier . In recent years, studies have found podocyte injury plays a key role in the pathogenesis of DKD. The study of the mechanism of podocyte injury is a hot topic in the field of kidney disease, but the mechanism of its injury is still not completely elucidated. This review summarizes the research progress of DKD podocyte injury mechanism.