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群体感应(quorum sensing,QS)广泛存在于病原菌,并与其致病性密切相关,如细菌侵染过程、毒力因子表达和细菌生物膜的形成~([1])。传统抗菌药物通过干扰病原菌的生化代谢过程,影响其结构与功能,达到抑制或杀死细菌作用。在这种生存选择压力下,易诱导细菌产生耐药性~([2])。群体感应抑制剂(quorum-sensing inhibitors,QSIs)能够抑制细菌QS系统,显著减弱其致病性~([3]),但对细菌生长影响小,因此具有不易诱导细菌耐药的优点,已经成为新型抗菌药物研发热点。本文就近年来致病菌QS系统及QSIs研究进展进行综述。
Quorum sensing (QS) is widespread in pathogenic bacteria and is closely related to its pathogenicity, such as bacterial infection, virulence factor expression and bacterial biofilm formation (1). Traditional antibacterial drugs interfere with the pathogen’s biochemical metabolic process, affecting its structure and function, to inhibit or kill bacteria. Under the pressure of survival and selection, easy to induce bacterial resistance (~) [2]. Quorum-sensing inhibitors (QSIs) can inhibit the bacterial QS system and significantly reduce their pathogenicity ([3]), but have little effect on bacterial growth and thus have the advantage of not being easy to induce bacterial resistance and have become New antibacterial research and development hot spots. This review summarizes the research progress of pathogen QS system and QSIs in recent years.