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目的探讨２０１Ｔｌ脑肿瘤ＳＰＥＣＴ显像判断颅内肿瘤组织学等级的价值。方法对７例正常对照者、３例脑血肿和５０例颅内肿瘤患者分别行２０１Ｔｌ脑显像。静脉注射２０１Ｔｌ１１１ＭＢｑ１５ｍｉｎ和３ｍｉｎ后，分别行早期和延迟脑ＳＰＥＣＴ显像，视觉分析颅内２０１Ｔｌ分布情况，并对７例正常者和２５例颅内肿瘤及３例脑血肿患者进行半定量分析，计算早期和延迟显像的摄取指数及滞留指数。结果正常对照者脑实质不显像；３例脑血肿病人早期显像可见血肿部位有放射性浓聚，延迟显像该部位放射性明显变淡；脑肿瘤组早期显像均见肿瘤部位有放射性浓聚，但摄取指数在各类脑肿瘤中无明显差异；而在延迟显像中其摄取指数根据肿瘤组织学不同有显著差异；高度恶性肿瘤组延迟显像摄取指数明显增加，滞留指数均大于１１４，而低度恶性和良性组的延迟显像摄取比值下降或无明显变化，滞留指数均小于１１０。结论２０１Ｔｌ脑ＳＰＥＣＴ显像可以探查脑肿瘤及其术后残存或复发，用于鉴别脑肿瘤的良恶性程度，其中滞留指数与肿瘤的组织学等级密切相关
Objective To investigate the value of SPECT imaging in determining the grade of intracranial tumors on 201Tl brain tumors. Methods Totally 201 Tl brain imaging was performed on 7 normal controls, 3 cerebral hematomas and 50 intracranial tumors. 201Tl111MBq15min and 3min after intravenous injection, respectively, early and delayed brain SPECT imaging, visual analysis of intracranial 201Tl distribution, and seven cases of normal and 25 cases of intracranial tumors and 3 cases of cerebral hematoma in patients with semi-quantitative analysis of early And delayed imaging of the uptake index and retention index. Results In normal control group, brain parenchyma was not visualized. In early stage of brain hematoma in 3 cases, there was radioactive accumulation in the hematoma site and delayed radioactivity in this site. , But the uptake index had no significant difference in all kinds of brain tumors; while in delayed imaging, the uptake index was significantly different according to tumor histology; the index of delayed imaging uptake was significantly increased in the group of high-grade tumors with retention index greater than 1. 14, while the ratio of delayed imaging uptake in low grade and benign group decreased or did not change obviously with retention index less than 110. Conclusion 201Tl brain SPECT imaging can explore the brain tumor and its residual or recurrence after surgery for the identification of benign and malignant brain tumors, which retention index is closely related to the histological grade of the tumor