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目的对西安市中心医院质子泵抑制剂在儿科的应用情况进行分析,为规范和指导临床合理用药、加强儿童用药监护提供依据。方法采用回顾性调查方法,利用医院PASS系统,统计2015年西安市中心医院质子泵抑制剂在住院患儿的使用情况,针对品种选择、适应症、给药剂量、溶媒选择及给药途径等分析合理性。结果质子泵抑制剂在住院患儿中的使用人次及销售金额均以兰索拉唑粉针剂为首。观察的79份病例中,不合理用药现象主要包括选药品种不适宜、无适应症用药、用法用量及给药途径不适宜、重复用药等。结论西安市中心医院质子泵抑制剂在患儿中的使用存在不合理现象,建议加强该类药物的规范化管理,以便在提高药效的同时降低患儿的用药风险。
Objective To analyze the application of proton pump inhibitors in pediatrics in Xi’an Central Hospital and provide the basis for standardizing and directing clinical rational drug use and strengthening child drug custody. Methods The retrospective investigation method was used to analyze the use of proton pump inhibitors in hospitalized children in the Central Hospital of Xi’an in 2015 according to the PASS system of the hospital. According to the analysis of selection, indications, dosage, solvent selection and route of administration rationality. Results The use of proton pump inhibitors in hospitalized children and the amount of sales were led by lansoprazole powder. Of the 79 observed cases, the phenomenon of irrational drug use mainly includes unsuitable drug selection, drug use without indication, inappropriate dosage and route of administration, and repeated medication. Conclusion There is an unreasonable use of proton pump inhibitors in children in Xi’an Central Hospital. It is suggested to strengthen the standardized management of such drugs in order to reduce the risk of medication in children while improving the efficacy.