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目的 通过观察c - jun原癌基因在鼠牙胚中的表达 ,探讨成牙本质细胞分化的转录调节。 方法 利用免疫组化方法检测c- jun原癌基因在鼠牙胚中的表达。 结果 c - jun原癌基因在小鼠牙胚的蕾状期、帽状期呈阴性表达 ,在钟状期牙胚的成牙本质细胞中呈阳性表达。结论 c -jun可能参与了成牙本质细胞分化的转录调节 ,并且可能成为成牙本质细胞的标志分子之一
Objective To investigate the transcriptional regulation of odontoblast differentiation by observing the expression of c-jun oncogene in rat tooth germ. Methods Immunohistochemical method was used to detect the expression of c-jun proto-oncogene in rat tooth germ. Results The c-jun proto-oncogene was negatively expressed in the bud stage and cap stage of the tooth germ and was positively expressed in the odontoblast of the bell stage tooth germ. Conclusion c-jun may be involved in transcriptional regulation of odontoblast differentiation and may be one of the markers of odontoblasts.