Acute myelogenous leukemia(AML)can involve the gastrointestinal tract but rarely involves the appendix. We report a male patient who had 1 year partial remission from AML and who presented with apparent acute appendicitis as the initial manifestation of leu-kemia relapse.Pathological findings of the appendix revealed transmural infiltrates of myeloblasts,which indicated a diagnosis of leukemia.Unfortunately,the patient died from progression of the disease on the 19th d after admission.Although leukemic cell infiltration of the appendix is uncommon,patients with leu-kemia relapse can present with symptoms mimicking acute appendicitis. We report a male patient who had 1 year partial remission from AML and who presented with apparent acute appendicitis as the initial manifestation of leu-kemia relapse. Pathological findings of Acute myelogenous leukemia (AML) the appendix revealed transmural infiltrates of myeloblasts, which indicates a diagnosis of leukemia. Unfortunately, the patient died from progression of the disease on the 19th d after admission. Though leukemic cell infiltration of the appendix is ​​uncommon, patients with leu-kemia relapse can present with symptoms mimicking acute appendicitis