目的　研究老年男性中血清瘦素与血糖和年龄的相互关系及其探讨临床意义。方法　用放射免疫分析法测定34例老年男性的瘦素,胰岛素等指标并进行相关性分析。结果　在老年人中,瘦素与年龄和血糖正相关r=0.6180,p=0.0052;r=0.5705, p=0.0263);正常血糖组的瘦素和年龄明显高于高血糖组(p= 0. 0415, p= 0.0033)。结论　随着年龄的增加,血糖升高,导致瘦素分泌的增加。瘦素在血糖调节中具有重要的作用。 Objective To investigate the relationship between serum leptin and blood glucose and age in elderly men and its clinical significance. Methods Radioimmunoassay was used to determine the levels of leptin and insulin in 34 elderly men and their correlations were analyzed. Results In the elderly, leptin was positively correlated with age and blood glucose (r = 0.6180, p = 0.0052; r = 0.5705, p = 0.0263). Leptin and age in normal glucose group were significantly higher than those in hyperglycemia group (p = 0. 0415, p = 0.0033). Conclusion With the increase of age, the blood sugar rises, leading to the increase of leptin secretion. Leptin plays an important role in the regulation of blood glucose.