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目的观察并比较双氯芬酸钠利多卡因和哌替啶各联合山莨菪碱治疗肾绞痛的疗效及安全性。方法 280例肾绞痛患者随机分为观察组和对照组各140例,观察组:一次性同时肌内注射双氯芬酸钠利多卡因2ml(含双氯芬酸钠75mg,利多卡因20mg)和山莨菪碱10mg;对照组一次性同时肌内注射哌替啶75mg和山莨菪碱10mg。观察比较两种方法给药后1h内的镇痛效果及不良反应。结果两组的镇痛效果无明显差异(P>0.05),但不良反应比较差异具有统计学意义(P<0.01)。结论双氯芬酸钠利多卡因与哌替啶用于肾绞痛疗效相似,但不良反应少,无成瘾性,临床应用方便,值得推广。
Objective To observe and compare the efficacy and safety of diclofenac sodium and lidocaine plus anisodamine in treating renal colic. Methods Two hundred and eighty patients with renal colic were randomly divided into observation group (140 cases) and control group (140 cases). The observation group received intramuscular injection of diclofenac sodium lidocaine 2ml (diclofenac sodium 75mg, lidocaine 20mg) and anisodamine 10mg ; Control group, intramuscular injection of pethidine 75mg and anisodamine 10mg at the same time. Observe and compare analgesic effect and adverse reaction within 1h after administration of the two methods. Results There was no significant difference in analgesic effect between the two groups (P> 0.05), but the adverse reaction was statistically significant (P <0.01). Conclusion Diclofenac sodium lidocaine and pethidine for the treatment of renal colic have similar efficacy, but with less adverse reactions, no addiction, clinical application is convenient and worth promoting.