中枢神经系统恶性淋巴瘤是一种罕见神经系统肿瘤.本文报告12例,其中男8例,女4例.单发11例,其中幕上7例、幕下4例、多发1例.临床表现无特殊性.好发部位幕上为额叶,幕下为小脑半球,且常累及脑室、胼胝体、硬膜和大脑镰.肿瘤病理组织学表现同身体其他部位恶性淋巴瘤,治疗采用手术和放疗为主,化疗为辅的原则.但病人预后差. Central nervous system malignant lymphoma is a rare tumor of the nervous system.There are 12 cases reported in this paper, including 8 males and 4 females, 11 cases were solitary, including 7 cases of supratentorial, 4 cases of inferior and 1 case of multiple clinical manifestations. Specificity .Small parts of the curtain for the frontal lobe, tentorium for the cerebellar hemispheres, and often involving the ventricle, corpus callosum, dura mater and falx.Cancer histopathological manifestations of other parts of the body with malignant lymphoma, the use of surgery and radiotherapy-based , Supplemented by the principle of chemotherapy, but the patient’s prognosis is poor.