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肝脏疾病与凝血机制、血小板功能有着极密切的关系。Deutsch统计至少有85％的肝脏病有一项以上的凝血试验异常,大约15％发生出血,肝脏疾病是引起继发性凝血障碍的常见疾病。肝硬化是常见慢性进行性肝病,主要是肝脏慢性弥漫性炎症、广泛的肝实质变性、坏死及大量纤维组织增生的疾病。肝脏是机体重要的凝血因子生成器官。肝硬化的肝细胞损害,常常可造成凝血因子的生成减少,当并发脾功能亢进时也可导致血小板量和质的改变,造成临床出凝血综合征,为了了解肝硬化所致的凝血障碍、血小板功能障碍的发病机制,我们在1985年系统研究了10例
Liver disease and coagulation mechanisms, platelet function has a very close relationship. Deutsch Statistics At least 85% of liver diseases have more than one clotting test abnormalities, about 15% of which develop bleeding. Liver disease is a common cause of secondary coagulopathy. Cirrhosis is a common chronic progressive liver disease, mainly chronic diffuse inflammation of the liver, extensive liver parenchymal degeneration, necrosis and a large number of fibrous tissue hyperplasia of the disease. The liver is an important clotting factor producing organ in the body. Cirrhosis of the liver cells damage, often can cause the formation of clotting factor reduced, when concurrent hypersplenism can also lead to changes in platelet mass and quality, resulting in clinical out of coagulation syndrome, in order to understand the cirrhosis caused by coagulation disorders, platelets The pathogenesis of dysfunction, we systematically studied in 1985 10 cases