论文部分内容阅读
目的了解结核病人中艾滋病患病和治疗、管理和转归情况,为建立TB/HI V双重感染病人的监测系统,制定治疗和管理机制提供依据。方法对确诊的活动性肺结核病人中用酶联免疫吸附试验(ELISA)和免疫印迹法(WB)进行筛查和确认HI V阳性患者。病人的治疗和管理按照《中国结核病控制项目实施工作指南》和《艾滋病防治工作手册》实施。结果结核病人中HI V/AIDS检出率为1·35%。结核病人规则治疗为51·28%,不规则治疗为48·72%,治愈率为10·25%,死于结核病、非结核病、HI V/AIDS为28%;而HI V/AIDS接受一线药物治疗为20%,病情好转为50%,死于结核病、非结核病、HI V/AIDS为36%,病人的丢失为40%,未接受抗艾滋病病毒治疗占74%,痰结核分枝杆菌培养阳性7株,其中1株为初始耐多药菌。结论结核病和HI V/AIDS双重感染者不规则治疗和管理是造成病人丢失、中断治疗、治愈(病程好转)率下降,导致死亡率增高的主要原因;TB/HI V双重感染者易发生耐药机会。
Objective To understand the prevalence and treatment, management and prognosis of AIDS among TB patients and to provide a basis for establishing a monitoring system and setting up a treatment and management mechanism for patients with TB / HI V infection. Methods The positive patients with HI V were screened and confirmed by enzyme - linked immunosorbent assay (ELISA) and western blot (WB) in diagnosed active pulmonary tuberculosis patients. The treatment and management of patients should be implemented in accordance with the Guidelines for the Implementation of China’s Tuberculosis Control Project and the AIDS Prevention and Treatment Workbook. Results The prevalence of HI V / AIDS among TB patients was 1.35%. Tuberculosis patients received 51.28% of regular treatment, irregular treatment of 48.72% and cure rate of 10.25%, died of tuberculosis and non-tuberculosis, HI V / AIDS was 28%; while HI V / AIDS received first-line drugs Treatment was 20%, condition improved to 50%, died of tuberculosis, non-TB, HI V / AIDS was 36%, the patient’s loss was 40%, did not receive anti-HIV treatment accounted for 74%, sputum positive Mycobacterium tuberculosis culture 7 strains, of which 1 was the initial multi-drug resistant bacteria. Conclusion Irregular treatment and management of patients with TB and HI V / AIDS infection are the main reasons leading to the loss of patients, discontinuation of treatment and cure (improvement of course of disease), leading to the increase of mortality rate. TB / HI V dual infection is susceptible to drug resistance opportunity.