PAMAM相关论文
脱嘌呤/脱嘧啶核酸内切酶1（APE1）是一种表达于不同亚细胞间的蛋白酶,在不同的生理功能中发挥着重要作用。APE1的异常表达和亚细胞功......
糖尿病加重了牙周炎的发病风险和严重程度,使糖尿病患者的牙周炎治疗成为一个巨大的挑战。纳米药物递送系统具有提高药物利用率、......
NEDD8是一种泛素样蛋白（Ubiquitin-like protein,UBL）,它介导Neddylation类泛素化修饰过程。同泛素一样,NEDD8在细胞凋亡、DNA损伤、......
目的:在西方发达国家,年龄性黄斑变性（Age-related macular degeneration,AMD）已经成为50岁以上老年人、不可逆的严重眼病之一;随着......
Prepartion and adsorption behaviors of attapulgite functionalizend by hyperbranched dendritic polyam
Attapulgite(ATP)is a kind of hydrated magnesium aluminum silicate with unique fibrous or rod-like morphology and layer-c......
PAMAM dendrimer is a highly effective nanocarrier(Generally refers to G3-G7).But PAMAM dendrimer without modification ma......
引言：肿瘤已成为威胁人类健康的重要杀手，而目前主要的治疗手段--化疗由于药物的全身分布而产生巨大的毒副作用，使得化疗药物在治疗肿......
Dendrimers have been extensively explored as non-viral vectors due to their inherent advantages including well-defined m......
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Analysis on protein glycosylation is an emerging ?eld that promises great contributions to diverse areas such as disease......
Disulfide Cross-linked Low Generation Dendrimers with High Gene Delivery Efficiency, Low Cytotoxicit
Cationic poly(amidoamine) (PAMAM) dendrimers were widely used asnon-viral gene carriers. PAMAM dendrimer-based products ......
Cationic poly(amidoamine) (PAMAM) dendrimers were widely used as non-viral gene carriers [1].PAMAM dendrimer-based produ......
树枝状大分子是一种高度支化、三维立体的化合物。它具有一个核心以及从核心中延伸出来的支化单元、大量的表面官能团、可控的尺寸......
结肠癌(CRC)是世界上比较常见的癌症。临床上治疗CRC的最重要方法之一是化学疗法。迄今为止,已经开发出许多种用于化学疗法的药物......
采用反相高效液相色谱-二极管阵列检测器(RP-HPLC-DAD)和质谱(ESI-MS)联用技术，对合成的PAMAM化合物进行分析鉴定。采用Agilent......
微波作为一种新的合成方法颇受国内外化学届的重视,已广泛用于有机合成,无机材料合成,分子筛合成以及一些无机材料的组装等.本文报......
1 Introduction Singapore is one of the main exporters of aquarium fishes. Among the many varieties of fishes exported is......
为了提高水性聚氨酯耐水性等性能,以异佛尔酮二异氰酸酯(IPDI)、聚四亚甲基醚二醇(PTMG)、二羟甲基丙酸(DMPA)、1,4-丁二醇(BDO)等......
目的:利用不同代数的聚酰胺-胺(PAMAM)制备分散性良好的多壁碳纳米管/聚酰胺-胺(MWCNTs-PAMAM)。方法:通过酰胺化法,将G3.0、G4.0......
以乙二胺为中心核,丙烯酸甲酯为支化单体,苯甲醛为端基官能团合成了3.0代和4.0代两种聚酰胺胺-苯甲醛树状大分子。对其荧光性能进......
通过固相合成的方法将聚酰胺-胺树状大分子PAMAM担载于大孔硅胶上,并对其外围分别用对羟基苯甲醛、2,4-二羟基苯甲醛和邻羟基苯甲......
To improve the dispersion of silica in polypropylene(PP) matrix and to avoid physical loss of the antioxidants, nanosili......
以乙二胺和丙烯酸甲酯为原料,经过重复Michael和酯氨解反应,制备出二代(2.0 G)树枝状聚酰胺胺(PAMAM).PAMAM与2,2,6,6-四甲基哌啶......
Due to their unique structural and physicochemical properties,dendrimers have been proposed as good candidates in potent......
结构性质独特的树形大分子有望在基因药物传递等生物医药领域有广阔应用。理解其在水溶液中的结构性质,对于其应用开发具有重要指......
以丙烯酸甲酯和乙二胺为原料,采用发散法合成了外围分别为4个、8个和16个—COOCH3的树枝状化合物(简记为MCMD4、MCMD8和MCMD16),在......
基因治疗通过基因载体将治病基因导入病患的特异细胞以治疗心血管、神经系统疾病和癌症等。寻找安全高效的非病毒基因载体一直是基......
采用粗粒化的分子动力学模拟研究了跨膜多肽,lysine-flanked peptide(KALP),对第四代聚酰胺-胺(PAMAM)树枝形分子形态结构的影响.......
It is found that the fluorescence of aliphatic poly(amido amine)s including linear and hyperbranched ones can be dramati......
Adhesive peptides conjugated PAMAM dendrimer as a coating polymeric material enhancing cell response
This present work aims to functionalize poly(amidoamine)(PAMAM) dendrimers with various reported adhesive peptides, incl......
通过二代和四代聚酰胺-胺树枝状聚合物(G2和G4表示)末端分别修饰苯丙氨酸和色氨酸合成了多种新型聚合物载体,进而考察了其与质粒的......
通过发散法合成了不同代数的β-环糊精为核的聚酰胺-胺树状大分子(CP),进一步与水杨醛缩合得到3种水杨醛改性的β-环糊精为核的聚......
聚酰胺-胺(PAMAM)是目前最具应用前景的树枝状大分子(Dendrimer),它与表面活性剂相互作用后能够形成聚集体,这种聚集体能有效地改......
将具有聚集诱导荧光的4-(2-吡啶乙烯基)-1,8-萘酰亚胺单元通过酰胺化反应连接到聚酰胺-胺(PAMAM)树形分子上,制备了一种水溶性吡啶......
采用2.0 G聚酰胺-胺(PAMAM)、石墨烯(GS)和1-丁基-3-甲基咪唑基四氟硼酸盐复合膜修饰玻碳电极(PAMAM/GS/IL/GCE),包埋固定多环芳烃......
通过化学还原法制备了以石墨烯为核树状大分子包覆Co纳米复合材料。利用FTIR、TG、XRD和TEM对所制备产物进行了结构表征。考察了不......
Low generational polyamidoamine dendrimers to enhance the solubility of folic acid:A‘‘dendritic effe
Low generational(G0–G2,G for generation) polyamidoamine(PAMAM) dendrimers were investigated as enhancers to improve the......
将G4代PAMAM树状大分子与Tat肽(一种细胞穿透肽)偶联,并用BODIPY标记,合成得到了一种新型纳米尺度抗肿瘤药载体BPTs,并系统考察了......
树枝状大分子是一种具有精确三维结构的纳米材料。目前，对于树枝状大分子的研究，逐渐从合成和表征各式各样的树枝状大分子转向到对其......
Serum proteins represent an important class of drug and imaging agent delivery vectors.In this minireview,key advantages......
Preparation, Swelling and Antibacterial Behaviors of N-Succinyl Chitosan-g-Poly(Acrylic Acid-co-Acry
Superabsorbent hydrogels were prepared successfully from N-succinyl chitosan grafted poly(acrylic acid-co-acrylamide). T......
目的应用纳米材料聚酰胺-胺型(PAMAM)树枝状聚合物/逆病毒基础的质粒载体复合体,在表达水平、持续时间和细胞毒性三方面进行血友病......
以系列1.0、2.0代树状聚酰胺-胺(PAMAM)为桥联基,3-(3,5-二叔丁基-4-羟基苯基)丙酰氯为抗氧化基团,通过酰胺化缩合反应合成了系列......
目的研究聚乙二醇(polyethylene glycol,PEG)化聚酰胺-胺树状大分子(polyamidoamine dendrimer,PAMAM)的理化性质及其作为质粒DNA......
本文合成了一种α-环糊精(α-cyclodextrin,α-CD)与聚酰胺-胺(polyamidoamine,PAMAM)的接枝聚合物(Cy D-G1)。~1H核磁测试结果表......
