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  5. Calpastatin Prevents NFkB-Mediated Hyperactivation of Macrophages implications in foam cell formatio

Calpastatin Prevents NFkB-Mediated Hyperactivation of Macrophages implications in foam cell formatio

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：jishume
【摘 要】
：
Aims: Calpastatin (CAST), an endogenous calpain enzymes inhibitor, negatively regulates the cleavage of calpain targets and have been implicated in inflammatory
【作 者】
：
Zhihui Cai Xuefeng Shan Shuimei Zhang Zhi Huang 
【机 构】
：
DepartmentofBiotechnology,SchoolofLifeScienceandTechnology,JinanUniversity
【出 处】
：
2014年第十二届全国脂质与脂蛋白学术会议
【发表日期】
：
2014年10期
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Aims: Calpastatin (CAST), an endogenous calpain enzymes inhibitor, negatively regulates the cleavage of calpain targets and have been implicated in inflammatory diseases, but its role in foam cell formation and atherosclerosis has not been evaluated.In this study, we focus on the effects of CAST on NFkB-mediated hyperactivation of macrophages and the following implications in foam cell formation and atherogenesis.
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