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目的探析癌胚抗原(CEA)、CA199、CA724三种肿瘤标志物在直肠癌临床诊断中的应用价值。方法 88例经相关影像学检查确诊直肠癌患者作为研究对象,患者均空腹抽取静脉血测定血清中CEA、CA199、CA724等肿瘤标志物水平。对不同肿瘤标志物、联合检测敏感性、特异性、阳性预测值、阴性预测值进行比较。结果联合检测敏感性及阴性预测值达到87.5%、94.3%,与CEA、CA199、CA724单独检测相比均更高,比较差异有统计学意义(P<0.05)。结论 CEA、CA199、CA724在直肠癌临床诊断中均具有较大价值,而联合检测则可进一步提高敏感性,实现直肠癌患者早期确诊,诊断价值显著,可推广应用。
Objective To investigate the clinical value of CEA, CA199 and CA724 in the clinical diagnosis of rectal cancer. Methods Eighty-eight patients with rectal cancer diagnosed by related imaging examination were selected as study subjects. All patients received fasting venous blood to measure the levels of CEA, CA199 and CA724 in serum. The sensitivity, specificity, positive predictive value and negative predictive value of different tumor markers and joint detection were compared. Results The sensitivity and the negative predictive value of combined detection reached 87.5% and 94.3%, respectively, which were higher than those of CEA, CA199 and CA724 alone. The difference was statistically significant (P <0.05). Conclusions CEA, CA199 and CA724 are of great value in the clinical diagnosis of rectal cancer. However, the combined detection can further increase the sensitivity and realize the early diagnosis of rectal cancer patients. The diagnosis value of CEA, CA199 and CA724 is significant and can be popularized and applied.