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目的:了解MA,TRF,IgG及轻链(λ,κ)的检测在肾脏疾病中的临床意义。方法:采用定时散射比浊法检测30例慢性肾小球肾炎,30例肾病综合征,26例慢性肾衰(尿毒症期)及40例健康者尿MA,TRF,IgG及轻链(λκ)的含量。结果:①慢性肾小球肾炎组尿MA,TRF,IgG及轻链κ含量与正常对照组相比差别有统计学意义(P<0.01),但轻链λ的含量与正常对照组差别无统计学意义(P>0.05)。②各类肾病患者五种尿微量蛋白浓度都显示与疾病的严重程度有关。高低依次为慢性肾功能衰竭(尿毒症期)患者>肾病综合征患者>慢性肾小球肾炎患者。结论:检测MA,TRF,IgG及轻链(λ,κ)的含量对肾脏疾病的诊断有重要的临床意义。
Objective: To investigate the clinical significance of detection of MA, TRF, IgG and light chain (λ, κ) in renal diseases. Methods: Thirty cases of chronic glomerulonephritis, 30 cases of nephrotic syndrome, 26 cases of chronic renal failure (uremia) and 40 cases of healthy subjects were tested for urine MA, TRF, IgG and light chain (λκ) by time - Content. Results: ① The levels of urinary MA, TRF, IgG and light chain κ in chronic glomerulonephritis group were significantly lower than those in normal control group (P <0.01), but there was no statistical difference between light chain λ content and normal control group Significance (P> 0.05). ② various types of renal disease in patients with urinary microalbumin concentrations have shown that the severity of the disease. The order was chronic renal failure (uremia) patients> nephrotic syndrome patients> chronic glomerulonephritis patients. Conclusion: The detection of MA, TRF, IgG and light chain (λ, κ) content of the diagnosis of renal disease has important clinical significance.