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从1985年底起,我地区发生耐氯霉素伤寒流行,从患者中分离出来的伤寒杆菌同时对治疗伤寒的常用抗生素如氨苄青霉素、复方新诺明和痢特灵等均耐药。据至1986年底70例分析,用上述药物联用或交替使用,疗效很差,平均退热时间18.9天,复发率为28.6％。1987年1～12月,我们试用利福平治疗这类伤寒患者,取得较为满意的效果,特报告如下:材料和方法病例选择:治疗组和对照组均系成人,均经血培养检出伤寒杆菌,药敏试验证实为耐氯霉素株。利福平组102例,本组病例治疗前用治疗伤寒的常用药物
Since the end of 1985, the epidemic of chloramphenicol-resistant typhoid has occurred in our region. Salmonella typhi isolated from the patients are also resistant to commonly used antibiotics for typhoid fever such as ampicillin, cotrimoxazole and furazolidone. According to the analysis of 70 cases by the end of 1986, with the above drugs in combination or alternation, the curative effect was very poor with an average of 18.9 days of fever and the recurrence rate was 28.6%. From January to December 1987, we tried rifampicin to treat such typhoid fever patients with satisfactory results. The special report is as follows: Materials and Methods Case Selection: The treatment group and the control group were all adults, , Susceptibility test confirmed that chloramphenicol resistant strains. Rifampicin group 102 cases, the group before treatment with commonly used drugs for the treatment of typhoid fever