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本文作者对83例骨髓增生异常综合征(MDS)患者染色体分析结果做总结并报告如下: 83例MDS患者,男54例、女29例,中位年龄63岁,最大87、最小18岁。按FAB标准,RA23例、RARS7例、RAEB25例、CMML8例、RAEB-T 20例。化疗前对每个患者行首次染色体分析,随后对30例病人的染色体做跟踪性分析。首次分析结果:83例病人中,50例有克隆性染色体异常,占60%,MDS亚型间染色体异常发生率无显性差异(P>0.1)。染色体异常最常见类型为7-单体型(-7)或7号染色体长臂缺失(7q~-)和5号染色体长臂缺失(5q),分别见于5例(RAEB、RAEB-T各2例,RA 1例)、9例(RAEB-T 5例,RAEB 2例,RA、
The authors summarize the chromosomal analysis of 83 patients with myelodysplastic syndrome (MDS) and report the following: 83 patients with MDS, 54 males and 29 females, with a median age of 63 years, a maximum of 87 and a minimum of 18 years. According to FAB standard, RA23 cases, RARS7 cases, RAEB25 cases, CMML8 cases, RAEB-T20 cases. Each patient was given a first chromosome analysis prior to chemotherapy followed by a follow-up analysis of the chromosomes of 30 patients. The first analysis: 83 of the patients, 50 cases of clonal chromosomal abnormalities, accounting for 60%, MDS subtypes, the incidence of chromosomal abnormalities was no significant difference (P> 0.1). The most common types of chromosomal abnormalities are the long arm deletion (7q ~ -) of chromosome 7 or chromosome 7 and the long arm deletion (5q) of chromosome 5, which are found in 5 cases (2 cases each of RAEB and RAEB-T 1 case of RA), 9 cases (5 cases of RAEB-T, 2 cases of RAEB, RA,