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目的 研究 7-硝基吲唑 (7- NI)在大鼠脑缺血后的保护作用。方法 用线栓法建立大鼠大脑中动脉缺血模型。用 7- NI(选择性 n NOS抑制剂 )研究了鼠脑缺血过程中脑组织 NOS活性变化 ,脑梗死体积以及梗死外周区神经元变化。结果 7- NI明显抑制了神经元型 NOS活性 ,减少了脑梗死体积并显著减轻了神经元缺血早期变性变化。结论 7- NI对缺血急性期脑组织有明显保护作用。
Objective To study the protective effect of 7-nitroindazole (7-NI) after cerebral ischemia in rats. Methods The rat middle cerebral artery occlusion model was established by thread occlusion. The changes of NOS activity, cerebral infarction volume and the changes of neurons in infarct peripheral zone were studied with 7-NI (selective nNOS inhibitor). Results 7-NI significantly inhibited the neuronal NOS activity, decreased the volume of cerebral infarction and significantly reduced the early degeneration of neuronal ischemia. Conclusion 7-NI has significant protective effect on acute ischemic brain tissue.