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目的:探讨血同型半胱氨酸(Hcy)水平与脑卒中发生的相关性,以及脑卒中患者血清叶酸(FA),维生素B12(VitB12)水平的变化。方法:分别对脑卒中患者(72例脑梗死,49例脑出血)及60名健康体检者(对照组)进行血Hcy、FA、VitB12的水平检测,并进行相关分析;另对脑卒中组其中48例血Hcy升高患者检测治疗前后血Hcy、FA、VitB12水平变化,并进行相关分析。结果:脑卒中组血Hcy水平显著高于对照组(P<0.01),而脑卒中组FA、VitB12水平则显著低于对照组(P<0.01);脑卒中组的组间血Hcy、FA、VitB12水平无差异(P>0.05);脑卒中组高Hcy血症患者血Hcy、FA、VitB12检测水平在治疗前后均有统计学意义(P<0.01)。结论:血Hcy升高与脑卒中有密切关系;血清FA、VitB12是影响血Hcy水平的原因之一。
Objective: To investigate the correlation between blood homocysteine (Hcy) level and stroke, and the changes of serum folic acid (FA) and vitamin B12 (VitB12) in patients with stroke. Methods: The blood levels of Hcy, FA and VitB12 in stroke patients (72 cerebral infarctions, 49 cerebral hemorrhages) and 60 healthy subjects (control group) were measured and analyzed. In the stroke group, 48 cases of patients with elevated serum Hcy detection of blood levels of Hcy, FA, VitB12 levels before and after the correlation analysis. Results: The blood levels of Hcy in the stroke group were significantly higher than those in the control group (P <0.01), while the levels of FA and VitB12 in the stroke group were significantly lower than those in the control group (P <0.01) (P> 0.05). The levels of serum Hcy, FA and VitB12 in patients with stroke were significantly higher than those before treatment (P <0.01). Conclusion: The increase of blood Hcy is closely related to stroke. Serum FA and VitB12 are one of the reasons that affect the level of blood Hcy.