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目的评价牛痘疫苗致炎兔皮提取物治疗带状疱疹后遗神经痛(PHN)的临床效果。方法带状疱疹后遗神经痛患者87例,随机分为A、B两组,A组为对照组,给予常规的止痛、营养神经、理疗等综合治疗,B组在A组治疗方案的基础上给予牛痘疫苗致炎兔皮提取物3.6IU/次,bid,im,共15d。分别于就诊时(T0)、治疗7d(T1)、半月(T2)、1月(T3)时利用视觉模拟评分法评估两组病例的疼痛缓解程度、睡眠质量评估生活质量提高程度,并观察其不良反应。结果视觉模拟评分及睡眠质量评估结果:治疗后,A、B两组较治疗前均显著改善(P<0.01),B组治疗后随时间延长,疼痛缓解程度及睡眠质量改善越显著,各时间段均优于A组。且与A组相比,B组并未出现恩再适所致的过敏、肝损害等不良反应。结论牛痘疫苗致炎兔皮提取物可明显地减轻PHN患者疼痛、改善睡眠,提高生活质量,起效快,效果明显,且安全性好。
Objective To evaluate the clinical efficacy of Vaccinium japonicum vaccination induced rabbit skin epidermolysis extract (PHN) in the treatment of postherpetic neuralgia (PHN). Methods 87 cases of postherpetic neuralgia patients were randomly divided into A, B two groups, A group as the control group, given conventional analgesics, nutrition nerves, physical therapy and other comprehensive treatment, B group in the A group based on the treatment plan Given vaccinia vaccination inflammation rabbit skin extract 3.6IU / time, bid, im, a total of 15d. Visual acuity scores were used to assess the degree of pain relief in both groups at the time of treatment (T0), 7d (T1), half moon (T2) and January (T3), and the quality of sleep was assessed. Adverse reactions. Results Visual analog scale and sleep quality assessment results: After treatment, the A and B groups improved significantly (P <0.01), and the B group prolonged with time after treatment, and the degree of pain relief and sleep quality improvement were significantly improved. At each time The segments were better than the A group. And compared with the A group, B group did not appear En again due to allergies, liver damage and other adverse reactions. Conclusion The vaccination of vaccinia rabbit skin extract can significantly reduce the pain of patients with PHN, improve sleep, improve quality of life, rapid onset, the effect is obvious, and the safety is good.