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目的：观察超氧化物歧化酶（ＳＯＤ）和脂质过氧化物（ＬＰＯ）在消化性溃疡（ＰＵ）治疗前后变化，以探索其对ＰＵ发病和愈合作用。方法：用ＳＵＮ法和于树玉法分别测定ＰＵ患者血及组织中铜锌超氧化物歧化酶（ＣｕＺｎＳＯＤ）活性和ＬＰＯ含量。结果：１８０例十二指肠溃疡（ＤＵ）和４２例胃溃疡（ＧＵ）患者粘膜和红细胞中ＣｕＺｎＳＯＤ活性比正常组显著降低（Ｐ＜０．０１～０．００１）。１３６例ＤＵ组织及血中和１５例ＧＵ组织中ＬＰＯ含量比正常组显著升高（Ｐ＜００１～０．００１）。用呋喃唑酮、雷尼替丁和洛赛克分别治疗５０、２０和２４例ＤＵ患者两周后组织中ＣｕＺｎＳＯＤ活性比治疗前明显升高（Ｐ＜０．０１～０．００１）。组织中ＬＰＯ含量比治疗前明显降低（Ｐ＜０００５～０．００１）。组织和红细胞中ＣｕＺｎＳＯＤ活性从活动期→愈合期→瘢痕期逐渐升高，而ＬＰＯ含量则逐渐降低。结论：粘膜组织中ＣｕＺｎＳＯＤ活性和ＬＰＯ含量升降与消化性溃疡的愈合和发病密切相关。
Objective: To observe the changes of superoxide dismutase (SOD) and lipid peroxides (LPO) before and after the treatment of peptic ulcer (PU) in order to explore the pathogenesis and healing of PU. Methods: The activity of Cu-ZnSOD and the content of LPO in the blood and tissues of patients with PU were determined by SUN and Yu Shuyu respectively. Results: CuZnSOD activity in mucosa and erythrocytes in 180 cases of duodenal ulcer (DU) and 42 cases of gastric ulcer (GU) was significantly lower than that in normal group (P <0.01 ~ 0.001). The serum levels of LPO in 136 cases of DU and 15 cases of GU were significantly higher than those in normal group (P <001 ~ 0.001). After treatment with furazolidone, ranitidine and Losec respectively, the CuZnSOD activity in the tissues of 50, 20 and 24 cases of DU patients was significantly higher than that before treatment (P <0.01 ~ 0.001). The content of LPO in the tissue was significantly lower than that before treatment (P <0005 ~ 0.001). The activities of CuZnSOD in tissues and erythrocytes gradually increased from active stage to healing and scarring, while the content of LPO decreased gradually. Conclusion: The activity of CuZnSOD and the increase and decrease of LPO content in mucosal tissues are closely related to the healing and pathogenesis of peptic ulcer.