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在日本,IgA肾病是最常见的原发性肾小球肾炎,组织学以系膜区IgA为特征,多为系膜增殖性肾小球肾炎。有研究发现白细胞介素6(IL-6)与系膜增殖性肾小球肾炎的发病机制密切相关。为探讨尿中IL-6的活性与IgA肾病预后之间的关系,作者测定了正常人和IgA肾病患者尿中IL-6的活性,并比较了IL-6与临床指标以及病理变化之间的关系。病人与方法:本研究包括20例正常人和32例IgA肾病患者(排除了系统性疾病和肾功能不全(Ccr>70ml/分)。根据肾活检系膜增殖的程度32例IgA肾病患者分为两组,Ⅰ组:24例,轻度系膜增殖;Ⅱ组:8例,中度系膜增殖(50%以上的肾小球有系膜增殖,肾小球局灶硬化和新月体形成在20%以上,间质纤维化和细胞浸润占皮质的30%以下)。32例IgA肾病患者有10例尿IL-6活性升高。这些病人随访10个月,Ⅱ组5例病人再次做肾活检。尿IL-6活性用IL-6鼠杂交克隆MH60,BSF_2测定。
In Japan, IgA nephropathy is the most common primary glomerulonephritis. Histology is characterized by mesangial IgA, mostly mesangial proliferative glomerulonephritis. Some studies have found that interleukin 6 (IL-6) and mesangial proliferative glomerulonephritis are closely related to the pathogenesis. To investigate the relationship between urinary IL-6 activity and the prognosis of IgA nephropathy, the authors measured urinary IL-6 activity in normal and IgA nephropathy patients and compared IL-6 with clinical markers and pathological changes relationship. PATIENTS AND METHODS: This study included 20 normal subjects and 32 patients with IgA nephropathy (excluding systemic disease and renal insufficiency (Ccr> 70 ml / min.) According to the extent of renal biopsy mesangial proliferation, 32 patients with IgA nephropathy were divided into Two groups, Ⅰ group: 24 cases, mild mesangial proliferation; Ⅱ group: 8 cases, moderate mesangial proliferation (more than 50% of glomerular mesangial proliferation, focal glomerular sclerosis and crescent formation In more than 20%, interstitial fibrosis and cell infiltration accounted for 30% of the cortex) .32 patients with IgA nephropathy in 10 cases of urinary IL-6 activity increased in these patients were followed up for 10 months, 5 patients in group Ⅱ again Renal biopsy Urinary IL-6 activity was measured using IL-6 mouse hybridization clone MH60, BSF_2.