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以磷灰石-硅灰石(AW)生物活性多孔玻璃陶瓷支架材料为基体,采用物理包被法制备了壳聚糖(CS)/AW复合多孔支架材料,通过红外图谱分析、扫描电镜、光学显微镜、强度检测等分析测试方法,研究了复合材料的组成、微观结构、力学和矿化性能。结果发现:复合材料与AW多孔支架材料基体相比,仍具有三维贯通且分布均匀的孔隙结构,孔径尺寸约100~500μm,孔隙率为80%左右,且力学性能明显增强,平均抗压强度可达3.11 MPa,比多孔AW支架材料基体的平均抗压强度提高了8.3倍。体外模拟体液浸泡实验表明,复合材料具有较高的矿化功能,预示材料具有较好的生物活性。这种复合材料可望作为人体非承重部位的植入骨修复体和组织工程支架使用。
The apatite / wollastonite (AW) bioactive porous glass ceramic scaffold material was used as substrate, and chitosan (CS) / AW composite scaffold material was prepared by physical coating method. Microscopy, strength testing and other analytical methods to study the composition, microstructure, mechanical and mineralization properties of the composites. The results show that the composites still have a three-dimensional through-hole and uniform distribution of pore structure compared with the matrix of AW porous scaffolds. The pore size is about 100-500 μm and the porosity is about 80%. The mechanical properties are obviously enhanced. The average compressive strength Up to 3.11 MPa, 8.3 times higher than the average compressive strength of porous AW scaffold matrix. In vitro simulated body fluid immersion experiments show that the composite material has a high mineralization function, indicating that the material has good biological activity. This composite material is expected to be used as an implantable bone prosthesis and a tissue engineering scaffold for non-load bearing parts of the body.