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红细胞(RBC)流变学特征受到损害时会严重影响脑微循环血流动力学。由于此处毛细血管直径比 RBC 直径小,所以 RBC 要变形后才能通得过。RBC 膜含多种磷脂,血小板活化因子(PAF)是一种具有很强生物活性的磷脂。在卒中和脑损害等病变中起着重要作用。PAF 可被血浆中 PAF 乙酰水解酶(PAF-AH)降解。脑血栓病人 RBC 质液中此酶活性降低。为此,作者对缺血性卒中病人 RBC 膜内PAF-AH 活性及其 RBC 变形能力之间的关系进行了研究。共研究有脑血栓病史的患者38例(男18,女20),年龄42～82(65±9.4)岁。卒中发生最短3个月,曾接受改善脑循环的己酮可可碱、甲磺酸二氢麦角碱、盐酸尼卡地平等药物。健康志愿者38人
Damage to the rheology of red blood cells (RBCs) can severely affect cerebral microcirculation hemodynamics. Since the diameter of the capillaries here is smaller than the diameter of the RBC, the RBC will not degenerate until it is deformed. RBC membrane contains a variety of phospholipids, platelet-activating factor (PAF) is a very bio-active phospholipids. It plays an important role in the pathogenesis of stroke and brain damage. PAF can be degraded in plasma PAF acetylhydrolase (PAF-AH). Cerebral thrombosis in RBC fluid of this enzyme activity decreased. To this end, the authors studied the relationship between PAF-AH activity and RBC deformability in RBC membranes of ischemic stroke patients. Thirty-eight patients (18 males and 20 females) with a history of cerebral thrombosis and 42 to 82 (65 ± 9.4) years of age were enrolled. Stroke occurred the shortest 3 months, had received to improve the cerebral circulation pentoxifylline, dihydroergotamine mesylate, nicardipine hydrochloride and other drugs. 38 healthy volunteers