肾间质细胞,尤其是成纤维细胞,在肾间质纤维化过程中起重要的作用。利用人肾髓质组织,成功地分离培养间质成纤维细胞,根据细胞形态及细胞结构蛋白(细胞角蛋白阴性、波形蛋白阳性和成纤维细胞表面抗原阳性)确定为成纤维细胞,同时根据细胞形态及细胞结构蛋白变化,提出成纤维细胞的增多部分是由小管上皮细胞转化为成纤维细胞。 Renal interstitial cells, especially fibroblasts, play an important role in the process of renal interstitial fibrosis. Human medullary tissue was used to isolate and culture mesenchymal fibroblasts successfully. Fibroblasts were identified as fibroblasts according to cell morphology and cell structure proteins (cytokeratin negative, vimentin positive and fibroblast surface antigen positive) Morphological and structural changes in cell protein, fibroblasts proposed increased part of the tubular epithelial cells into fibroblasts.