与传统的化学疗法相比,合理设计的分子靶向抗肿瘤药物具有高选择性和低毒性。目前,大多数此类药物均靶向于异常的生长信号。除不适当的生长信号外,许多癌细胞不能凋亡。Petersen等发现促细胞凋亡蛋白的小分子类似物可恢复一些癌细胞亚型的细胞凋亡,并解释了其作用机制。抗细胞 Compared with traditional chemotherapy, a well-designed molecularly targeted antitumor drug has high selectivity and low toxicity. Currently, most of these drugs target abnormal growth signals. In addition to inappropriate growth signals, many cancer cells fail to apoptosis. Petersen et al. Found that small analogs of pro-apoptotic proteins can restore apoptosis in some cancer cell subtypes and explain its mechanism of action. Anti-cell