根据54例IA肾病患者的临床表现及其病理改变,包括其免疫荧光,光镜和电镜检查进行综合分析.探讨IgA肾病的临床和病理关系,研究其间可能存在的规律性。结果临床各型IgA肾病的组织病理学都以轻微病变为主,但伴有高血压者例外,它以硬化型为主,有大量蛋白尿者其肾功能损害较重。结果提示对临床上不明原因的蛋白尿及血尿患者,必要时可作肾活组织检查以资鉴别诊断。 According to the clinical manifestations and pathological changes of 54 patients with IA nephropathy, including their immunofluorescence, light microscopy and electron microscopy, the clinical and pathological relationships of IgA nephropathy were explored and the possible regularities were discussed. Results The histopathology of IgA nephropathy in all clinical types were mainly mild lesions. However, with the exception of high blood pressure, it was mainly sclerosis. The patients with large proteinuria had severe renal damage. The results suggest that clinically unexplained proteinuria and hematuria patients, if necessary, can be used for renal biopsy differential diagnosis.