论文部分内容阅读
目的 :探讨嗜酸粒细胞白血病 (Eo L)的诊断标准。方法 :回顾性分析了 4例患者的临床资料 ,同时对有关文献进行了复习。结果 :Eol是嗜酸粒细胞恶性增殖性疾病 ,随访 2例治疗后死亡 ,1例 CR,1例出院不详。结论 :建议分型诊断标准为 :(1)急性嗜酸粒细胞白血病 :1外周血嗜酸粒细胞持续增高 (>1.5× 10 9/ L ) ,并出现不成熟嗜酸粒细胞和 /或不成熟粒细胞 ,有进行性血红蛋白和血小板减少 ;2骨髓原始粒细胞≥ 5 % ,各阶段嗜酸粒细胞增多 ,≥ 30 % ;3有嗜酸粒细胞恶性增殖的证据。 (2 )慢性嗜酸粒细胞白血病 :1外周血成熟嗜酸粒细胞持续增高(>1.5× 10 9/ L) ;2骨髓嗜酸粒细胞≥ 30 % ;3能除外其它已知原因所致的嗜酸粒细胞增多 ;4肝、脾肿大伴贫血和血小板减少或有嗜酸粒细胞恶性增殖的证据。
Objective: To investigate the diagnostic criteria of eosinophilic leukemia (Eo L). Methods: The clinical data of 4 patients were retrospectively analyzed. The related literature was also reviewed. RESULTS: Eol was a malignant proliferative disease of eosinophils. Two patients died after follow-up treatment. One case was CR, and one patient was discharged. Conclusion: The recommended diagnostic criteria are: (1) Acute eosinophilic leukemia: 1 Persistent elevation of eosinophils in peripheral blood (>1.5 × 10 9 / L) with immature eosinophils and/or absent Mature granulocytes, with progressive hemoglobin and thrombocytopenia; 2 bone marrow blasts ≥ 5%, eosinophilia at each stage, ≥ 30%; 3 evidence of malignant proliferation of eosinophils. (2) Chronic eosinophilic leukemia: 1 Peripheral blood mature eosinophils continued to increase (>1.5 × 10 9 / L); 2 bone marrow eosinophils ≥ 30%; 3 can be caused by other known causes Eosinophilia; 4 liver, splenomegaly with anemia and thrombocytopenia or evidence of malignant proliferation of eosinophils.