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用环磷酰胺、植物血凝素调节巨噬细胞的活性,观察了伯喹脂质体的抗疟效果。经注射环磷酰胺(200mg/kg)的伯喹脂质体组,小鼠肝组织单位面积(cm~2)疟原虫红外期数为0 211667±0.143961,疟原虫平均直径(A.M.D)为11.8350±1.84021μm;伯喹组单位面积(cm~2)红外期数为0.61425±0.35730,疟原虫平均直径为16.0418±4.8604μm,两组有显著性差异(P<0.05)。伯喹脂质体组与注射植物血凝素的伯喹脂质体组的抗疟效果未见提高。提示巨噬细胞活性的改变可影响伯喹脂质体的抗疟效果。
Cyclophosphamide and phytohemagglutinin were used to regulate the activity of macrophages, and the anti-malarial effect of beijoe liposomes was observed. The injection of cyclophosphamide (200mg / kg) of the Puerarin liposome group, the mouse liver tissue per unit area (cm ~ 2) of the parasite infrared number was 0211667 ± 0.143961, the average diameter of the malaria parasite (AMD) was 11.8350 ± 1.84021μm. The number of primordial per unit area (cm ~ 2) was 0.61425 ± 0.35730 and the average diameter of Plasmodium was 16.0418 ± 4.8604μm. There was a significant difference between the two groups (P <0.05). There was no improvement in the anti-malarial effect of the emodin liposomes group and the phytohemagglutinin-administered emodin liposomes group. It is suggested that the change of macrophage activity may affect the anti-malarial effect of beijoe liposomes.