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慢性乙型肝炎病毒(HBV)感染是指有乙型肝炎或HBsAg阳性史超过6个月,现在HBsAg和(或)HBV DNA仍为阳性者。根据血清、生化、病毒学和辅助检查可将慢性乙肝病毒感染分为慢性乙型肝炎、乙肝肝硬化、携带者和隐匿性慢性乙型肝炎4种。而全球约有一半的人生活在HBV感染的高流行区,3-4亿人为慢性HBV感染者,其中15％-25％的患者最终将死于肝硬化和肝癌, 为解决这一全球性公共卫生难题,世界各地的肝病专家针对当地患者的具体情况,制订了各自不同的治疗指南。尽管地域不同,但每个指南中均以抗病毒治疗作为主要内容,其重要性由此可略见一斑。
Chronic hepatitis B virus (HBV) infection refers to those with a positive history of hepatitis B or HBsAg for more than 6 months now with HBsAg and / or HBV DNA still positive. Chronic hepatitis B virus infection can be divided into 4 chronic hepatitis B, hepatitis B cirrhosis, carriers and occult chronic hepatitis B according to serum, biochemistry, virology and auxiliary examination. About half of the world’s population lives in a high-prevalence area of HBV infection and 3-4 billion people are chronically infected with HBV. Fifteen to 25% of these patients will eventually die of cirrhosis and liver cancer. To address this global public Health problems, liver disease experts around the world for the specific situation of local patients, developed their own different treatment guidelines. The importance of antiretroviral therapy in each guide, although geographically distinct, is clear.