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24只家兔(48只眼)滤过术后,随机分为高三尖杉酯碱组、5-FU 组、对照组,每组16只眼。术后第1周内每日一次、第2周内隔日一次,分别球结膜下注射高三尖杉酯碱0.06mg、5-FU5mg、注射用水0.2ml。结果显示:与对照组相比,高三尖杉酯碱与5-FU 皆具有明显抑制纤维增殖的功效,在眼压控制、滤枕持续天数方面,二者作用相当。而结膜下纤维细胞数目观察,高三尖杉酯碱明显优于5-FU 组,且高三尖杉酯碱副作用发生率较5-FU 低。
Twenty-four rabbits (48 eyes) were randomly divided into homoharringtonine group, 5-FU group and control group, with 16 eyes in each group. The first postoperative week once a day, the second week after every other day, were subconjunctival injection of homoharringtonine 0.06mg, 5-FU5mg, 0.2ml water for injection. The results showed that compared with the control group, homoharringtonine and 5-FU all have the obvious effect of inhibiting the proliferation of the fiber. The number of conjunctival fibroblasts, homoharringtonine was significantly better than 5-FU group, and the incidence of homoharringtonine side effects than 5-FU low.