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目的探讨Er:YAG激光备洞对牙髓的生物学效应。方法雄性SD大鼠66只随机分为实验组与对照组,实验组大鼠左上第一磨牙用高速牙钻备洞,右上第一磨牙用Er:YAG激光备洞,对照组大鼠磨牙不作任何处理。于不同时段分批处死大鼠,取标本做HE染色进行牙髓组织病理学观察,免疫组化染色法观察牙髓内降钙素基因相关肽(calcitonin cene-related peptide,CGRP)的表达。结果 Er:YAG激光备洞后牙髓组织病理学改变及降钙素基因相关肽的表达改变恢复正常要快于高速牙钻备洞。结论 Er:YAG激光备洞对牙髓的刺激小。
Objective To investigate the biological effects of Er: YAG laser on dental pulp. Methods Sixty-six male Sprague-Dawley rats were randomly divided into experimental group and control group. In the experimental group, the upper left first molar was drilled with high-speed dental drill, the upper right first molar was prepared with Er: YAG laser, while the control rats deal with. The rats were sacrificed at different time points and HE staining was performed to observe the histopathological changes of dental pulp. The expression of calcitonin cene-related peptide (CGRP) in dental pulp was observed by immunohistochemical staining. Results The pathological changes of pulp tissue and the expression of calcitonin gene - related peptide in hole after Er: YAG laser were restored to normal faster than those of high speed dental drill. Conclusion The Er: YAG laser hole has little stimulation to dental pulp.