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MCI-154化学名为6-[4-(4-吡啶氨基)苯基]-4,5-二氢-3(2H)哒嗪酮,具有很强的强心、扩张血管和抗血小板聚集作用[1],其强心作用的机制完全不同于强心甙类和儿茶酚胺类强心药,前者是通过抑制细胞内磷酸二酯酶,提高细胞内AMP水平而发挥作?
MCI-154 has the chemical name of 6- [4- (4-pyridylamino) phenyl] -4,5-dihydro-3 (2H) pyridazinone, which has strong cardiac, dilated blood vessels and anti-platelet aggregation [1] The mechanism of its cardiac effect is totally different from that of cardiac glycosides and catecholamines. The former works by inhibiting intracellular phosphodiesterase and increasing intracellular AMP levels.