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本文根据近年组胺H_2受体拮抗剂研究状况及有效药物结构的初探,设计、合成了十一个胍基噻唑衍生物,经体外药理筛选,证明所试的三个化合物,具有一定的拮抗H_2受体的活性。
In this paper, according to the research status of histamine H 2 receptor antagonists in recent years and the preliminary study of effective drug structure, eleven guanidinothiazole derivatives were designed and synthesized. Three in vitro pharmacological tests showed that the three compounds tested had antagonistic effect on H 2 Receptor activity.