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目的:探讨血小板计数与骨肉瘤患者远处转移和预后的关系。方法:将53例骨肉瘤患者分为转移组与无转移组,分别统计入院时、术前和术后2周血小板计数,并进一步对其中43例患者进行生存分析,比较术前血小板计数对生存率的影响。结果:术前血小板计数>300×109L-1的19例患者中有16例(84.2%)术后出现远处转移,而术前血小板计数≤300×109L-1的34例患者中有19例(55.9%)出现转移,两者比较差异有统计学意义,χ2=4.361,P=0.037。进一步比较术前血小板增多组与术前血小板术增多组间的生存率,差异有统计学意义,q=4.96,P=0.026。多因素分析提示,术前血小板计数升高是骨肉瘤患者死亡的危险因素,P=0.032。结论:术前血小板计数升高与骨肉瘤远处转移相关且是骨肉瘤预后的高危因素。
Objective: To investigate the relationship between platelet count and distant metastasis and prognosis in patients with osteosarcoma. Methods: Fifty-three patients with osteosarcoma were divided into metastasis group and non-metastasis group. The platelet counts at admission, preoperative and postoperative 2 weeks were calculated, and 43 patients were further analyzed for survival. Preoperative platelet count was compared to survival Rate of impact. RESULTS: Sixteen (84.2%) of the 19 patients with preoperative platelet count> 300 × 109 L-1 had distant metastases after surgery, compared with 19 of 34 patients with preoperative platelet count ≤300 × 109 L-1 (55.9%), the difference was statistically significant (χ2 = 4.361, P = 0.037). Further comparison between preoperative thrombocytosis group and preoperative thrombocytosis increased survival rate between groups, the difference was statistically significant, q = 4.96, P = 0.026. Multivariate analysis showed that preoperative platelet count was a risk factor for mortality in osteosarcoma patients, P = 0.032. CONCLUSIONS: The elevated preoperative platelet count is associated with distant metastases of osteosarcoma and is a risk factor for the prognosis of osteosarcoma.