五苓散粉末,用时以自来水配制成混悬液,每日1次,灌胃给药。 实验1为短期给药实验。将大鼠分为对照组及五苓散0.5、1.0、2.0g/kg四组,连续给药7天,1.0g/kg剂量相当于人10倍量,对照组仅给水。第7日末次给药后3h时令动物吸入CCl_4气20min,第24、48h测定血清AST、ALT值;吸入CCl_4第24h各组取6只,解剖取肝进行组织学检查。结果,五苓散1.0g/kg组吸入CCl_4 24h后 Five powders, when used as a suspension prepared with tap water, once daily, administered by gavage. Experiment 1 is a short-term administration experiment. The rats were divided into control group and Wuhao Powder group (0.5, 1.0, 2.0g/kg). The continuous administration was carried out for 7 days. The dose of 1.0g/kg was equivalent to 10 times that of the human. The control group only fed water. At the 3rd hour after the last administration on the 7th day, the animals were inhaled with CCl_4 for 20 minutes, and the serum AST and ALT values ​​were measured at 24th and 48th hour; 6 rats in each group were taken 24h after inhalation of CCl 4 , and the liver was dissected for histological examination. As a result, Wulu Powder 1.0g/kg group inhaled CCl_4 after 24h