论文部分内容阅读
青光眼是致盲的主要眼病之一 ,滤过手术是目前抗青光眼手术的主要术式。术后球结膜下形成有功能的滤过泡是治疗成功的关键所在。而青光眼滤过手术失败的主要原因则是非功能性滤过泡 ,其主要原因是创伤组织胶原纤维增多和过度瘢痕化。有研究证实 ,青光眼滤过术后滤过道瘢痕形成的病理机制与局部组织重塑和细胞表型转化有关 ,但关于局部组织重塑发生机制尚不清楚。我们对参与滤过泡瘢痕形成的局部组织重塑和免疫调节机制 ,以及对药物治疗滤过泡过度瘢痕化作一综述
Glaucoma is one of the main eye diseases caused by blindness. Filtering surgery is the main surgery for anti-glaucoma surgery. Postoperative subconjunctival formation of functional filtration bleb is the key to the success of the treatment. The main reason for the failure of glaucoma filtration surgery is non-functional filtration bleb, the main reason is the increase in collagen fibers and scarring of the trauma. Studies have confirmed that the pathological mechanism of scar formation in the filtration tract after glaucoma filtration is related to local tissue remodeling and cell phenotyping, but the mechanism of local tissue remodeling is unclear. We review the mechanisms of local tissue remodeling and immunoregulation involved in the formation of scarring of filtration bleb and the over-scarring of drug-treated bleb