l-脯氨酸催化下,以含有卤原子、不同类型的烷基及烷氨基取代苯甲醛类化合物、苯乙酮和醋酸铵为原料,合成了8个2,6-二苯基-4-芳基取代吡啶化合物,对相关合成条件进行了归纳总结,产物经核磁共振、质谱、红外等进行表征,并进一步进行了初步的抗菌活性测试. Under the catalysis of l-proline, eight 2,6-diphenyl-4- (4-hydroxyphenyl) ethanesulfonic acid compounds were synthesized by the reaction of different types of alkyl and alkylamino substituted benzaldehydes with acetophenone and ammonium acetate as raw materials. Aryl-substituted pyridine compounds, the synthesis conditions were summarized, the products were characterized by NMR, MS and IR, and further preliminary antibacterial activity test.