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目的 探讨睾丸切除术对血清 β 淀粉样蛋白 (Aβ)的影响。 方法 选择 45只 3年老龄健康雄性兔 ,实验组 3 0只切除双侧睾丸 ,对照组 15只行开腹、关腹术。分时间段对实验组、对照组取外周静脉血 ,用放射免疫方法监测Aβ水平的变化。 结果 术前Aβ为 (2 2 5± 1 2 )ng/ml,实验组术后Aβ上升明显 ,术后 5周达最高峰(76 1± 2 8)ng/ml,以后逐渐下降 ,术后半年仍明显高于术前水平 (5 0 2± 2 7)ng/ml;对照组假手术对Aβ几乎无影响。结论 雄激素对Aβ生成或降解有影响 ,可能是通过向雌激素转化减少而起作用
Objective To investigate the effect of orchidectomy on serum amyloid β (Aβ). Methods Forty-three healthy male rabbits aged 3 years were selected. The experimental group of 30 male and female testis were resected, while the control group of 15 male underwent abdominal surgery and abdominal surgery. Peripheral blood was collected from the experimental group and control group in different time periods, and the level of Aβ was monitored by radioimmunoassay. Results The preoperative Aβ level was (225 ± 1 2) ng / ml. The Aβ level in the experimental group increased significantly at the 5th week after operation, reaching the peak at 761 ± 28 ng / ml after the operation, and then gradually decreased after 6 months Still significantly higher than the preoperative level (502 ± 27) ng / ml; sham operation in the control group had little effect on Aβ. Conclusions Androgens have an effect on the production or degradation of Aβ, probably by decreasing the conversion of estrogen